Home Hippo TEAD inhibitor IK-930 For research use only.

IK-930

IK-930 is a selective, small-molecule inhibitor of TEAD that prevents palmitate binding and thereby disrupts aberrant TEAD-dependent transcription. IK-930 demonstrates antitumor activity in mouse xenograft models with Hippo pathway genetic alterations.

IK-930 Chemical Structure

IK-930 Chemical Structure

CAS No. 2563892-44-2

Purity & Quality Control

Batch: E148301 DMSO]85 mg/mL]false]Ethanol]4 mg/mL]false]Water]Insoluble]false Purity: 99.01%
99.01

IK-930 Related Products

Biological Activity

Description IK-930 is a selective, small-molecule inhibitor of TEAD that prevents palmitate binding and thereby disrupts aberrant TEAD-dependent transcription. IK-930 demonstrates antitumor activity in mouse xenograft models with Hippo pathway genetic alterations.
Targets
TEAD [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05228015 Recruiting
Solid Tumors Adult|Solid Tumor|Malignant Pleural Mesothelioma (MPM)|Epithelioid Hemangioendothelioma (EHE)|NF2 Deficient Mesothelioma|Other NF2 Deficient Solid Tumors and Solid Tumors With YAP1/TAZ Fusion Genes|NF2 Deficiency|YAP1 or TAZ Gene Fusions
Ikena Oncology
 January 7 2022 Phase 1

Chemical Information & Solubility

Molecular Weight 424.44 Formula

C19H19F3N4O2S
CAS No. 2563892-44-2 SDF Download IK-930 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 85 mg/mL ( (200.26 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 4 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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