Home Metabolism Glucosylceramide Synthase inhibitor Ibiglustat succinate For research use only.

Ibiglustat succinate

Synonyms: Venglustat succinate

Ibiglustat succinate (Venglustat succinate) is a glucosylceramide (GlcCer) synthase inhibitor that blocks the formation of glucosylceramide.

Ibiglustat succinate Chemical Structure

Ibiglustat succinate Chemical Structure

CAS No. 1629063-78-0

Purity & Quality Control

Batch: E064601 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]100 mg/mL]false Purity: 98.67%
98.67

Ibiglustat succinate Related Products

Biological Activity

Description Ibiglustat succinate (Venglustat succinate) is a glucosylceramide (GlcCer) synthase inhibitor that blocks the formation of glucosylceramide.
Targets
GlcCer synthase [1]
In vitro
In vitro

Ibiglustat succinate can prevent additional globotriaosylceramide(GL-3) accumulation and could serve to ameliorate the abundant levels of this sphingolipid in fabry disease cardiomyocytes.[2]
Cell Research Cell lines Fabry disease cardiomyocytes
Concentrations 1 μM
Incubation Time 15 days
Method

Embryoid bodies (EBs) are treated with 1 μM Ibiglustat succinate for 15 days. Culture medium with Ibiglustat succinate is replaced every 2 days during the 15 days of treatment. GL-3 clearance is tested once the GL3 accumulation reached the plateau. Twenty-eight days after the start of differentiation, beating EBs are treated with 1 μM of Ibiglustat succinate for 15 days or with 0.3 μg/ml of agalsidase beta for 5 days. Culture media with Ibiglustat succinate or agalsidase beta are replaced every 2 days. GL-3 accumulation is investigated by immunocytological (ICC), electron microscopy (EM), and mass spectrometry (MS) analysis.
In Vivo
In vivo

Venglustat administration signifcantly reduces the accumulation of glycosphingolipids and pathological α-synuclein aggregates in the central nervous system and ameliorated the associated memory defcit. [3]
Animal Research Animal Models Gaucher disease model mice(C57Bl/6)
Dosages 0.03%, 0.033%
Administration p.o.

Chemical Information & Solubility

Molecular Weight 523.58 Formula

C20H24FN3O2S.C4H6O5
CAS No. 1629063-78-0 SDF Download Ibiglustat succinate SDF
Smiles CC(C)(NC(=O)OC1CN2CCC1CC2)C3=CSC(=N3)C4=CC=C(F)C=C4.OC(CC(O)=O)C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (190.99 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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