Glucosylceramide Synthase

Glucosylceramide Synthase Products

All (4)
Glucosylceramide Synthase Inhibitors (3)
Glucosylceramide Synthase Modulator (1)
New Glucosylceramide Synthase Products

Catalog No.	Product Name	Information	Product Use Citations
S7852	Eliglustat	Eliglustat (GENZ-112638) inhibits glucosylceramide synthase(GCS) (IC50=20 nM in intact MDCK cells), thus reducing the load of glucosylceramide influx into the lysosome.	Eur J Pharmacol, 2024, 966:176366 Int J Mol Sci, 2023, 24(12)9905 Biochim Biophys Acta Mol Cell Biol Lipids, 2021, 1866(1):158817
S4433	Eliglustat hemitartrate	Eliglustat hemitartrate (Genz-112638, Eliglustat tartrate) is a potent, specific and orally active inhibitor of glucosylceramide synthase with IC50 of 24 nM.	Biochim Biophys Acta Mol Cell Biol Lipids, 2021, 1866(1):158817 Biol Pharm Bull, 2021, 44(10):1419-1426
E0646	Ibiglustat succinate	Ibiglustat succinate (Venglustat succinate) is a glucosylceramide (GlcCer) synthase inhibitor that blocks the formation of glucosylceramide.	Cell Rep, 2023, 42(12):113431
E0786	N-Desmethyltamoxifen	N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
S7852	Eliglustat	Eliglustat (GENZ-112638) inhibits glucosylceramide synthase(GCS) (IC50=20 nM in intact MDCK cells), thus reducing the load of glucosylceramide influx into the lysosome.	Eur J Pharmacol, 2024, 966:176366 Int J Mol Sci, 2023, 24(12)9905 Biochim Biophys Acta Mol Cell Biol Lipids, 2021, 1866(1):158817
S4433	Eliglustat hemitartrate	Eliglustat hemitartrate (Genz-112638, Eliglustat tartrate) is a potent, specific and orally active inhibitor of glucosylceramide synthase with IC50 of 24 nM.	Biochim Biophys Acta Mol Cell Biol Lipids, 2021, 1866(1):158817 Biol Pharm Bull, 2021, 44(10):1419-1426
E0646	Ibiglustat succinate	Ibiglustat succinate (Venglustat succinate) is a glucosylceramide (GlcCer) synthase inhibitor that blocks the formation of glucosylceramide.	Cell Rep, 2023, 42(12):113431
E0786	N-Desmethyltamoxifen	N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.

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