Home Neuronal Signaling AChR antagonist Hexamethonium Dibromide For research use only.

Hexamethonium Dibromide

Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.

Hexamethonium Dibromide Chemical Structure

Hexamethonium Dibromide Chemical Structure

CAS No. 55-97-0

Purity & Quality Control

Batch: S406901 Water]73 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 100.00%
100.00

Hexamethonium Dibromide Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic AChR in ganglia.
Targets
Dopamine subtype 2 receptor [1] AChR [1]
In vitro
In vitro Hexamethonium Bromide is effective against Ach and carbachol (CCh) on the amplitude of endplate responses of rat omohyoid muscle with EC50 of 300 μM and 100 μM, respectively. Hexamethonium Bromide (50-200 μM) causes an increase in the amplitude of nerve-evoked endplate currents (e.p.cs) recorded in the presence of 0.6 μM tubocurarine. Hexamethonium Bromide is also a weak inhibitor of acetylcholinesterase activity in rat muscle homogenates with EC50 of 1.5 mM. [1] Hexamethonium Bromide (200 μM) decreases the time constant of decay of both endplate currents (e.p.cs) (by ~25%) and miniature endplate currents (m.e.p.cs) (by ~20%) in the rat hemi-diaphragm muscle. At low frequencies of stimulation (0.5-2 Hz), Hexamethonium Bromide (200 μM) increases e.p.c. quantal content by 30-40%. [2]

Chemical Information & Solubility

Molecular Weight 362.19 Formula

C12H30N2.2Br
CAS No. 55-97-0 SDF Download Hexamethonium Dibromide SDF
Smiles C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]
Storage (From the date of receipt)

In vitro
Batch:

Water : 73 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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