Home Transmembrane Transporters GABA Receptor inhibitor Guvacine hydrochloride For research use only.

Guvacine hydrochloride

Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and displays modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).

Guvacine hydrochloride Chemical Structure

Guvacine hydrochloride Chemical Structure

CAS No. 6027-91-4

Purity & Quality Control

Batch: E223201 Water]33 mg/mL]false]DMSO]16 mg/mL]false]Ethanol]1 mg/mL]false Purity: 99.73%
99.73

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Biological Activity

Description Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and displays modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).

Chemical Information & Solubility

Molecular Weight 163.60 Formula

C6H10ClNO2
CAS No. 6027-91-4 SDF --
Smiles Cl.OC(=O)C1=CCCNC1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 33 mg/mL

DMSO : 16 mg/mL ( (97.79 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 1 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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