Home Transmembrane Transporters Sodium Channel inhibitor GS967 For research use only.

GS967

Synonyms: GS458967

GS967 (GS458967) is a potent and selective inhibitor of late INa with anti-arrhythmic actions.

GS967 Chemical Structure

GS967 Chemical Structure

CAS No. 1262618-39-2

Purity & Quality Control

Batch: S527401 Ethanol]46 mg/mL]false]DMSO]45 mg/mL]false]Water]Insoluble]false Purity: 99.98%
99.98

GS967 Related Products

Signaling Pathway

Sodium Channel Signaling Pathways

Sodium Channel Signaling Pathway

Biological Activity

Description GS967 (GS458967) is a potent and selective inhibitor of late INa with anti-arrhythmic actions.
Targets
late INa [1]
0.13 μM
In vitro
In vitro GS967 (3 μM) has no significant effect on L- or T-type calcium channel currents or Na+-Ca2+ exchanger current (INCX), and 1 μM GS967 has minimal or no effect on the ATP-inhibited K+ current or on human cardiac ion channels expressed in human embryonic kidney 293 or Chinese hamster ovary cells[1]. GS967 is a novel sodium channel modulatorspecifically developed to inhibit persistent sodium current, with a 42-fold preference for persistent as opposed to peakcurrent inhibition[2].
In Vivo
In vivo GS967 protects against seizures and prematurelethality in vivo. Chronic GS967 does not cause overt behavioraltoxicity or sedation in wild-type mice at theeffective anticonvulsant dose[2]. GS967 suppresses arrhythmogenicity evoked by ischemia, hypokalemia, and catecholamines in canine and porcine models[3].
Animal Research Animal Models New Zealand White adult females rabbits
Dosages 30, 60 and 120 µg/kg
Administration i.v.

Chemical Information & Solubility

Molecular Weight 347.22 Formula

C14H7F6N3O
CAS No. 1262618-39-2 SDF --
Smiles C1=CC(=CC=C1C2=CN3C(=NN=C3C(F)(F)F)C=C2)OC(F)(F)F
Storage (From the date of receipt)

In vitro
Batch:

Ethanol : 46 mg/mL

DMSO : 45 mg/mL ( (129.6 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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