Home MAPK Raf inhibitor GNE-9815 For research use only.

GNE-9815

GNE-9815 is a highly selective, pan-Raf inhibitor with good oral bioavailability. GNE-9815 exhibits Ki values of 0.062 and 0.19 nM for c-Raf and b-Raf, respectively.

GNE-9815 Chemical Structure

GNE-9815 Chemical Structure

CAS No. 2729996-45-4

Purity & Quality Control

Batch: E107901 DMSO]30 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.49%
99.49

GNE-9815 Related Products

Signaling Pathway

Raf Signaling Pathways

Raf Signaling Pathway

Biological Activity

Description GNE-9815 is a highly selective, pan-Raf inhibitor with good oral bioavailability. GNE-9815 exhibits Ki values of 0.062 and 0.19 nM for c-Raf and b-Raf, respectively.
Targets
C-Raf [1] B-Raf [1]
0.062 nM(Ki) 0.19 nM(Ki)

Chemical Information & Solubility

Molecular Weight 455.48 Formula

C26H22FN5O2
CAS No. 2729996-45-4 SDF --
Smiles CN1N=CC2=CC(=CN=C2C1=O)C3=CC(=C(F)C=C3C)NC(=O)C4=CC(=CC=C4)C(C)(C)C#N
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 30 mg/mL ( (65.86 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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