Home Neuronal Signaling AChR antagonist Glycopyrrolate For research use only.

Glycopyrrolate

Synonyms: Glycopyrrolate bromide, Glycopyrronium bromide, Robinul, Gastrodyn

Glycopyrrolate (Glycopyrronium, Robinul, Gastrodyn) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.

Glycopyrrolate Chemical Structure

Glycopyrrolate Chemical Structure

CAS No. 596-51-0

Purity & Quality Control

Glycopyrrolate Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description Glycopyrrolate (Glycopyrronium, Robinul, Gastrodyn) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
Targets
Muscarinic receptor [1]
In vitro
In vitro Glycopyrrolate inhibits EFS-induced contraction of guinea-pig trachea and human airways in a concentration-dependent manner. In competition studies, glycopyrrolate binds human peripheral lung and human airway smooth muscle (HASM) muscarinic receptors with affinities in the nanomolar range (Ki values 0.5–3.6 nM). Glycopyrrolate showed no selectivity in its binding to the M1–M3 receptors. Kinetics studies show that glycopyrrolate dissociates slowly from HASM muscarinic receptors[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06291363 Not yet recruiting
Opioid Use Unspecified|Anesthesia|Nociceptive Pain
Ciusss de L''Est de l''Île de Montréal
 April 4 2024 Phase 4
NCT04979039 Unknown status
Cesarean Section
Seoul National University Bundang Hospital
 August 1 2021 --
NCT04554589 Unknown status
Effect of Drugs
Tanta University
 September 14 2020 Phase 1

Chemical Information & Solubility

Molecular Weight 398.33 Formula

C19H28NO3.Br
CAS No. 596-51-0 SDF Download Glycopyrrolate SDF
Smiles C[N+]1(CCC(C1)OC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C.[Br-]
Storage (From the date of receipt)

In vitro
Batch:

Water : 79 mg/mL

DMSO : 65 mg/mL ( (163.18 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 59 mg/mL


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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