Choose Your Country or Region

GSH (Glutathione)

Name: GSH (Glutathione)
Brand: Selleck Chemicals
SKU: S4606
Rating: 5 (17 reviews)

Synonyms: Isethion, Glutathion, Tathion, L-Glutathione reduced, γ-L-Glutamyl-L-cysteinyl-glycine

Catalog No.S4606 Purity:99.97%

GSH (Glutathione) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.

GSH (Glutathione) Chemical Structure

CAS No. 70-18-8

Purity & Quality Control

Batch: Purity: 99.97%

99.97

GSH (Glutathione) Related Products

Related Products	DL-Buthionine-Sulfoximine	Click to Expand
Related Compound Libraries	Metabolism Compound Library Anti-cancer Metabolism Compound Library Glutamine Metabolism Compound Library Carbohydrate Metabolism Compound Library Lipid Metabolism Compound Library	Click to Expand

Biological Activity

Description	GSH (Glutathione) acts as an antioxidant, a free radical scavenger and a detoxifying agent. It is a tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue.

In vitro
In vitro	Glutathione (GSH) is able to recover the meiotic failure induced by heavy metal cadmium (Cd) exposure through suppressing the excessive ROS level, DNA damage accumulation and apoptotic incidence in porcine oocytes.^[2]
Cell Research	Cell lines	porcine oocytes
	Concentrations	1, 2 and 4 mM
	Incubation Time	--
	Method	Cadmium chloride is dissolved in PBS and diluted in TCM-199 medium to a final concentration of 0.4, 2, 10 and 50 μM, respectively. GSH is dissolved in PBS and diluted in TCM-199 medium to a final concentration of 1, 2 and 4 mM, respectively. Both cadmium chloride and GSH are supplemented to TCM-199 medium immediately before culture.

In Vivo
In vivo	Oral GSH can increase GSH concentrations in several tissues following GSH depletion.^[1]
Animal Research	Animal Models	Mice (outbred albino ICR, 30-40 g)
	Dosages	100 mg/kg
	Administration	oral administration

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT06205030	Not yet recruiting	Diabetes Mellitus Type 2\|Insulin Resistance	Kerman Medical University\|Afzalipour Hospital	June 14 2024	Phase 4

References

Chemical Information & Solubility

Molecular Weight	307.32	Formula	C₁₀H₁₇N₃O₆S
CAS No.	70-18-8	SDF	Download GSH (Glutathione) SDF
Smiles	C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N
Storage (From the date of receipt)	3 years -20°C(in the dark) powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C(in the dark) powder		1 month-20°Cin solvent

In vitro
Batch:

Water : 61 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):