Home Hippo LATS inhibitor GA-017 For research use only.

GA-017

GA-017 inhibits the serine/threonine protein kinases large tumor suppressor kinase 1/2 (LATS1/2), which exerts inhibitory with IC50s against LATS1 and 2 of 4.10±0.79 and 3.92±0.42 nM, respectively, and competitively inhibits LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58±0.11 and 0.25±0.03 nM, respectively.

GA-017 Chemical Structure

GA-017 Chemical Structure

CAS No. 2351906-74-4

Purity & Quality Control

Batch: E114501 DMSO]69 mg/mL]false]Ethanol]35 mg/mL]false]Water]Insoluble]false Purity: 99.23%
99.23

GA-017 Related Products

Biological Activity

Description GA-017 inhibits the serine/threonine protein kinases large tumor suppressor kinase 1/2 (LATS1/2), which exerts inhibitory with IC50s against LATS1 and 2 of 4.10±0.79 and 3.92±0.42 nM, respectively, and competitively inhibits LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58±0.11 and 0.25±0.03 nM, respectively.
Targets
LATS2 [1]
(in a double-reciprocal lineweaver-burk plot)		 LATS1 [1]
(in a double-reciprocal lineweaver-burk plot)		 LATS2 [1]
(in the kinase assay)		 LATS1 [1]
(in the kinase assay)
0.25 nM(Ki) 0.58 nM(Ki) 3.92 nM 4.10 nM

Chemical Information & Solubility

Molecular Weight 343.38 Formula

C18H21N3O4
CAS No. 2351906-74-4 SDF --
Smiles CC\C(=N\NC(=O)NCC1=CC(=CC=C1)O)C2=C(O)C(=C(O)C=C2)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 69 mg/mL ( (200.94 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 35 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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