LATS

LATS Products

All (4)
LATS Inhibitors (4)
New LATS Products

Catalog No.	Product Name	Information	Product Use Citations
E1314	TDI-011536	TDI-011536 is a potent Lats kinase inhibitor that interrupts Hippo-Yap signaling and promotes proliferation of lesioned cardiac muscle cells.	Nat Commun, 2024, 15(1):6953 Int J Mol Sci, 2024, 25(20)11234 bioRxiv, 2024, 2024.10.11.617852
E1061	TRULI	TRULI inhibits both Lats1 and Lats2 with a IC50 of 0.2 nM, suppresses Yap phosphorylation, induces cell proliferation in several cell lines and tissues, and promotes the initial stages of proliferative regeneration of the sensory receptors in the inner ear.	Nat Commun, 2024, 15(1):5449 Cell Rep, 2024, 43(4):114032 EMBO Rep, 2024, 25(9):4033-4061
E1145	GA-017	GA-017 inhibits the serine/threonine protein kinases large tumor suppressor kinase 1/2 (LATS1/2), which exerts inhibitory with IC50s against LATS1 and 2 of 4.10±0.79 and 3.92±0.42 nM, respectively, and competitively inhibits LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58±0.11 and 0.25±0.03 nM, respectively.
E4687^New	NIBR-LTSi	NIBR-LTSi is a selective small-molecule inhibitor of LATS kinase . It agonizes YAP signaling and promotes tissue regeneration in vitro and in vivo, supporting future research on the regenerative potential of the YAP/Hippo pathway.
E1314	TDI-011536	TDI-011536 is a potent Lats kinase inhibitor that interrupts Hippo-Yap signaling and promotes proliferation of lesioned cardiac muscle cells.	Nat Commun, 2024, 15(1):6953 Int J Mol Sci, 2024, 25(20)11234 bioRxiv, 2024, 2024.10.11.617852
E1061	TRULI	TRULI inhibits both Lats1 and Lats2 with a IC50 of 0.2 nM, suppresses Yap phosphorylation, induces cell proliferation in several cell lines and tissues, and promotes the initial stages of proliferative regeneration of the sensory receptors in the inner ear.	Nat Commun, 2024, 15(1):5449 Cell Rep, 2024, 43(4):114032 EMBO Rep, 2024, 25(9):4033-4061
E1145	GA-017	GA-017 inhibits the serine/threonine protein kinases large tumor suppressor kinase 1/2 (LATS1/2), which exerts inhibitory with IC50s against LATS1 and 2 of 4.10±0.79 and 3.92±0.42 nM, respectively, and competitively inhibits LATS1 and 2 against ATP, with Ki (inhibition constant) values of 0.58±0.11 and 0.25±0.03 nM, respectively.
E4687^New	NIBR-LTSi	NIBR-LTSi is a selective small-molecule inhibitor of LATS kinase . It agonizes YAP signaling and promotes tissue regeneration in vitro and in vivo, supporting future research on the regenerative potential of the YAP/Hippo pathway.
E4687^New	NIBR-LTSi	NIBR-LTSi is a selective small-molecule inhibitor of LATS kinase . It agonizes YAP signaling and promotes tissue regeneration in vitro and in vivo, supporting future research on the regenerative potential of the YAP/Hippo pathway.

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