For research use only. Not for use in humans.

Figitumumab (Anti-IGF1R / CD221)

Synonyms: CP-751871 Cat.No.A2942 Purity:99%

Figitumumab (Anti-IGF1R / CD221) is a human monoclonal antibody directed against the insulin-like growth factor type I receptor (IGF1R) with potential antineoplastic activity. Figitumumab prevents IGF1 from binding to IGF1R with an IC50 of 1.8 nM. MW: 146.0 KD.

Quality Control

Batch: A294201 Purity: 99% Protein concentration: 5.223mg/ml Endotoxin Level: ＜1EU/mg

Specificity

Name	Citation	IGF-1R	Insulin Receptor	Others
Linsitinib (OSI-906)	206	++	++	IRR
NVP-AEW541	65	+	++	FLT3,Tek,FLT1
GSK1904529A	26	+++	+++
NVP-ADW742	24	+
BMS-536924	26	++	++	FAK,MEK,LCK
AG-1024	27	+	+
GSK1838705A	18	++++	++++	ALK
BMS-754807	54	++++	++++	TrkB,Met,TrkA
PQ 401	3	+
Ginsenoside Rg5	0	++
XL228	0	++++		ABL T315I,LYN,Aurora A
Picropodophyllin (PPP)	45	++++
AZD3463	7	✔		ALK
S961	3		✔
Nordihydroguaiaretic acid (NDGA)	1	✔		p300,HER2,lipoxygenase

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Figitumumab (Anti-IGF1R / CD221) is a human monoclonal antibody directed against the insulin-like growth factor type I receptor (IGF1R) with potential antineoplastic activity. Figitumumab prevents IGF1 from binding to IGF1R with an IC50 of 1.8 nM. MW: 146.0 KD.
References	https://pubmed.ncbi.nlm.nih.gov/24107449/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	943453-46-1
Molecular Weight	146
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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