Home Transmembrane Transporters ATPase inhibitor Esomeprazole sodium For research use only.

Esomeprazole sodium

Synonyms: (S)-Omeprazole sodium, (-)-Omeprazole sodium

Esomeprazole Sodium((S)-Omeprazole sodium, (-)-Omeprazole sodium) is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg.

Esomeprazole sodium Chemical Structure

Esomeprazole sodium Chemical Structure

CAS No. 161796-78-7

Purity & Quality Control

Esomeprazole sodium Related Products

Signaling Pathway

ATPase Signaling Pathways

ATPase Signaling Pathway

Biological Activity

Description Esomeprazole Sodium((S)-Omeprazole sodium, (-)-Omeprazole sodium) is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg.
Targets
ATPase [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06213818 Recruiting
Healthy Participants
Incyte Corporation
 March 14 2024 Phase 1
NCT06275841 Recruiting
Healthy
Pfizer|Arvinas Estrogen Receptor Inc.
 February 23 2024 Phase 1
NCT05062876 Completed
Gastroesophageal Reflux Disease
Addpharma Inc.
 November 1 2021 Phase 1
NCT06181084 Completed
Healthy
Eli Lilly and Company|Loxo Oncology Inc.
 October 11 2021 Phase 1
NCT05061563 Completed
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men|Hot Flashes
Bayer
 September 30 2021 Phase 1

Chemical Information & Solubility

Molecular Weight 367.4 Formula

C17H18N3O3S.Na
CAS No. 161796-78-7 SDF Download Esomeprazole sodium SDF
Smiles CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=C(C=C3)OC.[Na+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 73 mg/mL ( (198.69 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 73 mg/mL

Ethanol : 73 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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