Home Transmembrane Transporters ATPase inhibitor Sodium orthovanadate For research use only.

Sodium orthovanadate

Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.

Sodium orthovanadate Chemical Structure

Sodium orthovanadate Chemical Structure

CAS No. 13721-39-6

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Sodium orthovanadate Related Products

Signaling Pathway

ATPase Signaling Pathways

ATPase Signaling Pathway

Biological Activity

Description Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.
Targets
(Na,K)-ATPase [2]
40 nM
In vitro
In vitro In transient forebrain ischemia, Sodium orthovanadate rescues cells from delayed neuronal death in the hippocampal CA1 region. The neuroprotective effects of Sodium orthovanadate and IGF-1 are associated with preventing decreased Akt-Ser-473 phosphorylation in the CA1 region observed immediately after reperfusion. Akt is moderately activated in the cell bodies and dendrites of pyramidal neurons after orthovanadate treatment. The Sodium orthovanadate treatment also prevents the decrease in phosphorylation of mitogen-activated protein kinase (MAPK). [3] Sodium orthovanadate inhibits ASK1 through the PI3-K/Akt-dependent pathway. [4] Sodium orthovanadate up-regulates Akt activity in the brain and in turn rescue neurons from delayed neuronal death by inhibiting FKHR-dependent or -independent death signals in neurons. [4]
In Vivo
In vivo In a rat model of myocardial ischemic infarction, sodium orthovanadate rescues cells from ischemia/reperfusion injuries. Post-treatment with Sodium orthovanadate reduces infarct size in a dose-dependent manner. [5] Sodium orthovanadate treatment also ameliorates contractile dysfunction of the left ventricle 72 hours after reperfusion. The cytoprotective action of Sodium orthovanadate treatment is closely associated with inhibition of fodrin breakdown. Sodium orthovanadate treatment inhibits caspase-3 activation induced by ischemia. [6]
Animal Research Animal Models Male Sprague-Dawley rats
Dosages 0.005 mL/min/100g of b.wt. over 20 minutes
Administration Administered via i.v.

Chemical Information & Solubility

Molecular Weight 183.91 Formula

Na3O4V
CAS No. 13721-39-6 SDF Download Sodium orthovanadate SDF
Smiles [O-][V](=O)([O-])[O-].[Na+].[Na+].[Na+]
Storage (From the date of receipt)

In vitro
Batch:

Water : 10 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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