Sodium orthovanadate

Catalog No.S2000 Batch:S200003

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Technical Data

Formula

Na3O4V
Molecular Weight 183.91 CAS No. 13721-39-6
Solubility (25°C)* In vitro Water 10 mg/mL (54.37 mM)
DMSO Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
Saline
30.0mg/ml Taking the 1 mL working solution as an example, add 30 mg of this product to 1 ml of physiological saline (0.9% NaCL solution), mix evenly to make it clear, The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM.
Targets
(Na,K)-ATPase [2]
40 nM
In vitro In transient forebrain ischemia, Sodium orthovanadate rescues cells from delayed neuronal death in the hippocampal CA1 region. The neuroprotective effects of Sodium orthovanadate and IGF-1 are associated with preventing decreased Akt-Ser-473 phosphorylation in the CA1 region observed immediately after reperfusion. Akt is moderately activated in the cell bodies and dendrites of pyramidal neurons after orthovanadate treatment. The Sodium orthovanadate treatment also prevents the decrease in phosphorylation of mitogen-activated protein kinase (MAPK). [3] Sodium orthovanadate inhibits ASK1 through the PI3-K/Akt-dependent pathway. [4] Sodium orthovanadate up-regulates Akt activity in the brain and in turn rescue neurons from delayed neuronal death by inhibiting FKHR-dependent or -independent death signals in neurons. [4]
In vivo In a rat model of myocardial ischemic infarction, sodium orthovanadate rescues cells from ischemia/reperfusion injuries. Post-treatment with Sodium orthovanadate reduces infarct size in a dose-dependent manner. [5] Sodium orthovanadate treatment also ameliorates contractile dysfunction of the left ventricle 72 hours after reperfusion. The cytoprotective action of Sodium orthovanadate treatment is closely associated with inhibition of fodrin breakdown. Sodium orthovanadate treatment inhibits caspase-3 activation induced by ischemia. [6]

Protocol (from reference)

Animal Study:[6]
  • Animal Models

    Male Sprague-Dawley rats

  • Dosages

    0.005 mL/min/100g of b.wt. over 20 minutes

  • Administration

    Administered via i.v.

Selleck's Sodium orthovanadate has been cited by 11 publications

The LCK-14-3-3ζ-TRPM8 axis regulates TRPM8 function/assembly and promotes pancreatic cancer malignancy [ Cell Death Dis, 2022, 13(6):524] PubMed: 35665750
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways [ Toxicol Appl Pharmacol, 2022, 441:115988] PubMed: 35307375
Pore-forming alpha-hemolysin efficiently improves the immunogenicity and protective efficacy of protein antigens [ PLoS Pathog, 2021, 17(7):e1009752] PubMed: 34288976
Design of ratiometric monoaromatic fluorescence probe via modulating intramolecular hydrogen bonding: A case study of alkaline phosphatase sensing [ Anal Chim Acta, 2021, 1143:144-156] PubMed: 33384112
SARS-CoV-2 Membrane Glycoprotein M Triggers Apoptosis With the Assistance of Nucleocapsid Protein N in Cells [ Front Cell Infect Microbiol, 2021, 11:706252] PubMed: 34513728
Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation [ PLoS Pathog, 2020, 16(7):e1008701] PubMed: 32735617
[ Cancer Immunol Res, 2019, ] PubMed: 30401677
Displacement Induced Off-On Fluorescent Biosensor Targeting IDO1 Activity in Live Cells. [ Anal Chem, 2019, 91(23):14943-14950] PubMed: 31714063
Characterization of Semaphorin 6A-Mediated Effects on Angiogenesis Through Regulation of VEGF Signaling. [ Methods Mol Biol, 2017, 1493:345-361] PubMed: 27787863
Rhodiola rosea suppresses thymus T-lymphocyte apoptosis by downregulating tumor necrosis factor-α-induced protein 8-like-2 in septic rats [Liu MW, et al. Int J Mol Med, 2015, 36(2):386-98] PubMed: 26063084

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.