Home Transmembrane Transporters CRM1

CRM1

CRM1 Products

  • All (7)
  • CRM1 Inhibitors (7)
  • New CRM1 Products
Catalog No. Product Name Information Product Use Citations Product Validations
S7252 Selinexor (KPT-330) Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2.
Oncogenesis, 2025, 14(1):1
Toxicol Lett, 2025, 406:31-37
Gastroenterology, 2024, S0016-5085(24)00062-3
S7551 Piperlongumine Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
NPJ Aging, 2025, 11(1):6
J Oral Biosci, 2024, S1349-0079(24)00071-9
J Exp Clin Cancer Res, 2023, 42(1):118
S8397 Eltanexor (KPT-8602) Eltanexor (KPT-8602, ONO-7706，ATG-016) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure.
J Transl Med, 2025, 23(1):62
Gastroenterology, 2024, S0016-5085(24)00062-3
Cells, 2024, 13(7)632
S7125 KPT-185 KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.
Cell Chem Biol, 2022, S2451-9456(22)00275-6
Oncotarget, 2020, 11(36):3371-3386
EMBO Rep, 2019, 20(11):e48150
S7707 Verdinexor (KPT-335) Verdinexor (KPT-335, ATG-527) is an orally bioavailable, selective XPO1/CRM1 inhibitor.
J Transl Med, 2025, 23(1):62
J Biomed Sci, 2022, 29(1):44
Cell Rep, 2022, 38(10):110472
S7251 KPT-276 KPT-276 is an orally bioavailable selective CRM1 inhibitor.
Elife, 2021, 10e67587
Front Oncol, 2020, 10:1424
Nat Commun, 2019, 10(1):3827
S7580 Leptomycin B Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM.
Cells, 2024, 13(22)1855
bioRxiv, 2024, 2024.04.24.590854
Cell Death Discov, 2023, 9(1):324
S7252 Selinexor (KPT-330) Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. Phase 2.
Oncogenesis, 2025, 14(1):1
Toxicol Lett, 2025, 406:31-37
Gastroenterology, 2024, S0016-5085(24)00062-3
S7551 Piperlongumine Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
NPJ Aging, 2025, 11(1):6
J Oral Biosci, 2024, S1349-0079(24)00071-9
J Exp Clin Cancer Res, 2023, 42(1):118
S8397 Eltanexor (KPT-8602) Eltanexor (KPT-8602, ONO-7706，ATG-016) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure.
J Transl Med, 2025, 23(1):62
Gastroenterology, 2024, S0016-5085(24)00062-3
Cells, 2024, 13(7)632
S7125 KPT-185 KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.
Cell Chem Biol, 2022, S2451-9456(22)00275-6
Oncotarget, 2020, 11(36):3371-3386
EMBO Rep, 2019, 20(11):e48150
S7707 Verdinexor (KPT-335) Verdinexor (KPT-335, ATG-527) is an orally bioavailable, selective XPO1/CRM1 inhibitor.
J Transl Med, 2025, 23(1):62
J Biomed Sci, 2022, 29(1):44
Cell Rep, 2022, 38(10):110472
S7251 KPT-276 KPT-276 is an orally bioavailable selective CRM1 inhibitor.
Elife, 2021, 10e67587
Front Oncol, 2020, 10:1424
Nat Commun, 2019, 10(1):3827
S7580 Leptomycin B Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM.
Cells, 2024, 13(22)1855
bioRxiv, 2024, 2024.04.24.590854
Cell Death Discov, 2023, 9(1):324

Choose Selective CRM1 Inhibitors

Tags: CRM1 inhibitor|CRM1 agonist|CRM1 activator|CRM1 inducer|CRM1 antagonist|CRM1 signaling pathway|CRM1 assay kit