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Encenicline (EVP-6124) hydrochloride
Encenicline (EVP-6124) hydrochloride is a selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.
Encenicline (EVP-6124) hydrochloride Chemical Structure
CAS No. 550999-74-1
Purity & Quality Control
Encenicline (EVP-6124) hydrochloride Related Products
| Related Targets | mAChR nAChR AChE | Click to Expand |
|---|---|---|
| Related Products | PNU-120596 Benzethonium Chloride Arecoline HBr Otilonium Bromide Lycorine Hyoscyamine (-)-Huperzine A (HupA) Nitenpyram Cytisine Chelidonine | Click to Expand |
| Related Compound Libraries | FDA-approved Drug Library Natural Product Library Neuronal Signaling Compound Library CNS-Penetrant Compound Library Anti-alzheimer Disease Compound Library | Click to Expand |
Signaling Pathway
Biological Activity
| Description | Encenicline (EVP-6124) hydrochloride is a selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. | ||
|---|---|---|---|
| Targets |
|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02246075 | Withdrawn | Alzheimer''s Disease|Dementia|Cognition |
FORUM Pharmaceuticals Inc|Quintiles Inc. |
July 2015 | Phase 2 |
| NCT02327182 | Terminated | Alzheimer''s Disease |
Mitsubishi Tanabe Pharma Corporation |
December 2014 | Phase 3 |
| NCT02004392 | Terminated | Alzheimer''s Disease|Dementia |
FORUM Pharmaceuticals Inc |
June 2014 | Phase 3 |
| NCT01969123 | Terminated | Alzheimer''s Disease|Dementia |
FORUM Pharmaceuticals Inc |
October 2013 | Phase 3 |
| NCT01969136 | Terminated | Alzheimer''s Disease|Dementia |
FORUM Pharmaceuticals Inc |
October 2013 | Phase 3 |
| NCT01984736 | Completed | Hepatic Impairment |
FORUM Pharmaceuticals Inc|PRA Health Sciences |
June 2013 | Phase 1 |
Chemical Information & Solubility
| Molecular Weight | 357.3 | Formula | C16H17ClN2OS.ClH |
| CAS No. | 550999-74-1 | SDF | -- |
| Smiles | Cl.ClC1=C2SC(=CC2=CC=C1)C(=O)NC3CN4CCC3CC4 | ||
| Storage (From the date of receipt) | 3 years -20°C powder | ||
|
In vitro |
DMSO : 71 mg/mL ( (198.71 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Ethanol : 35 mg/mL Water : Insoluble |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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