Donanemab (Anti-Amyloid Beta)

Synonyms: LY3002813

Catalog No.A2833 Purity:99%

Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody directed at an N‐terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab has the potential for early Alzheimer's disease research. MW : 145.36 KD.

Purity & Quality Control

Batch: A283301 Purity: 99% Protein concentration: 5.54mg/ml Endotoxin Level: ＜1EU/mg

Choose Selective Beta Amyloid Inhibitors

Name	Citation	Beta Amyloid	Others
DAPT	366	+++	Notch
RO4929097	115	+++	γ secretase,Notch
Semagacestat (LY450139)	20	+++	Notch
MK-0752	23	++++
Avagacestat (BMS-708163)	22	++++
LY2811376	19	++	BACE1
CRANAD-2	0	++
Hoechst 34580	1	+
Frentizole	0	+
Simufilam	✔
Ginsenoside Rg1	✔	NF-κB
Ginsenoside Re	✔	NF-κB,JNK
Tabersonine hydrochloride	✔
EUK 134	✔

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Biological Activity

Description	Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody directed at an N‐terminal pyroglutamate amyloid beta (Aβ) epitope. Donanemab has the potential for early Alzheimer's disease research. MW : 145.36 KD.

References
[1] Mintun MA, et al. N Engl J Med. 2021;384(18):1691-1704.

References

[1] Mintun MA, et al. N Engl J Med. 2021;384(18):1691-1704.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1931944-80-7
Molecular Weight	145.36
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100mMPro-Ac,20mMArg-Ac，pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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