Home Cell Cycle Nur77 antagonist DIM-C-pPhOH For research use only.

DIM-C-pPhOH

Synonyms: C-DIM8, CDIM8

DIM-C-pPhOH (C-DIM8, CDIM8) is a nuclear receptor 4A1 (NR4A1)(Nur77) antagonist. DIM-C-pPhOH inhibits tumor growth and mTOR signaling, induces apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively.

DIM-C-pPhOH Chemical Structure

DIM-C-pPhOH Chemical Structure

CAS No. 151358-47-3

Purity & Quality Control

DIM-C-pPhOH Related Products

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MCF7 Anticancer assay 2 uM 24 hrs Anticancer activity against human MCF7 cells assessed as cell death at 2 uM after 24 hrs by MTT assay 22104151
MCF7 Function assay 2 uM 24 hrs Inhibition of tubulin polymerization in human MCF7 cells at 2 uM after 24 hrs by FITC-conjugated immunostaining assay 22104151
MCF7 Function assay 2 uM 24 hrs Inhibition of HDAC1 protein expression in human MCF7 cells at 2 uM after 24 hrs by Western blotting 22104151
MCF7 Function assay 2 uM 24 hrs Inhibition of HDAC2 protein expression in human MCF7 cells at 2 uM after 24 hrs by Western blotting 22104151
MCF7 Function assay 2 uM 24 hrs Inhibition of HDAC3 protein expression in human MCF7 cells at 2 uM after 24 hrs by Western blotting 22104151
MCF7 Function assay 2 uM 24 hrs Inhibition of HDAC8 protein expression in human MCF7 cells at 2 uM after 24 hrs by Western blotting 22104151
MCF7 Function assay 8 uM 24 hrs Induction of apoptosis in human MCF7 cells assessed as PARP-cleavage at 8 uM after 24 hrs by Western blot analysis 22104151
MCF7 Function assay 8 uM 24 hrs Induction of apoptosis in human MCF7 cells assessed as caspase-7 activation at 8 uM after 24 hrs by Western blot analysis 22104151
Click to View More Cell Line Experimental Data

Biological Activity

Description DIM-C-pPhOH (C-DIM8, CDIM8) is a nuclear receptor 4A1 (NR4A1)(Nur77) antagonist. DIM-C-pPhOH inhibits tumor growth and mTOR signaling, induces apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively.
Targets
Nur77 [1]
(786-O cells based assay)		 Nur77 [1]
(ACHN cells based assay)
13.0 μM 13.6 μM

Chemical Information & Solubility

Molecular Weight 338.40 Formula

C23H18N2O
CAS No. 151358-47-3 SDF --
Smiles C1=CC=C2C(=C1)C(=CN2)C(C3=CC=C(C=C3)O)C4=CNC5=CC=CC=C54
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 68 mg/mL ( (200.94 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 68 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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