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Nur77

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Catalog No. Product Name Information Product Use Citations Product Validations
S6674 Cytosporone B Cytosporone B is a naturally occurring agonist for nuclear orphan receptor Nur77(NR4A1) with an EC50 of 0.278nM.
Mol Med, 2023, 29(1):63
Mol Med, 2023, 29(1):63
Signal Transduct Target Ther, 2021, 6(1):133
S0149 C-DIM5 C-DIM5 (DIM-C-pPhOCH3) is an agonist of Nur77 (Nerve growth factor-induced Bα (NGFI-Bα)/nuclear receptor 4A1 (NR4A1)) which is an orphan nuclear receptor. C-DIM5 (DIM-C-pPhOCH3) decreases survival and induces apoptosis in RKO colon cancer cells.
Cell Rep Med, 2024, S2666-3791(24)00234-9
Mol Psychiatry, 2022, 10.1038/s41380-022-01497-8
S6799 DIM-C-pPhOH DIM-C-pPhOH (C-DIM8, CDIM8) is a nuclear receptor 4A1 (NR4A1)(Nur77) antagonist. DIM-C-pPhOH inhibits tumor growth and mTOR signaling, induces apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively.
Cell Rep, 2024, 43(2):113746
Mol Psychiatry, 2022, 10.1038/s41380-022-01497-8
S6785 DIM-C-pPhCO2Me DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1)(Nur77) antagonist with antineoplastic activity.
S6799 DIM-C-pPhOH DIM-C-pPhOH (C-DIM8, CDIM8) is a nuclear receptor 4A1 (NR4A1)(Nur77) antagonist. DIM-C-pPhOH inhibits tumor growth and mTOR signaling, induces apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively.
Cell Rep, 2024, 43(2):113746
Mol Psychiatry, 2022, 10.1038/s41380-022-01497-8
S6785 DIM-C-pPhCO2Me DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1)(Nur77) antagonist with antineoplastic activity.
S6674 Cytosporone B Cytosporone B is a naturally occurring agonist for nuclear orphan receptor Nur77(NR4A1) with an EC50 of 0.278nM.
Mol Med, 2023, 29(1):63
Mol Med, 2023, 29(1):63
Signal Transduct Target Ther, 2021, 6(1):133
S0149 C-DIM5 C-DIM5 (DIM-C-pPhOCH3) is an agonist of Nur77 (Nerve growth factor-induced Bα (NGFI-Bα)/nuclear receptor 4A1 (NR4A1)) which is an orphan nuclear receptor. C-DIM5 (DIM-C-pPhOCH3) decreases survival and induces apoptosis in RKO colon cancer cells.
Cell Rep Med, 2024, S2666-3791(24)00234-9
Mol Psychiatry, 2022, 10.1038/s41380-022-01497-8

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