Home Neuronal Signaling AChR agonist Decamethonium Bromide For research use only.

Decamethonium Bromide

Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.

Decamethonium Bromide Chemical Structure

Decamethonium Bromide Chemical Structure

CAS No. 541-22-0

Purity & Quality Control

Batch: S407201 Water]84 mg/mL]false]DMSO]34 mg/mL]false]Ethanol]25 mg/mL]false Purity: 100.00%
100.00

Decamethonium Bromide Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description Decamethonium Bromide is a nicotinic AChR partial agonist and neuromuscular blocking agent.
Targets
nAChR [1]
In vitro
In vitro Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate, but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release. [1]

Chemical Information & Solubility

Molecular Weight 418.29 Formula

C16H38N2.2Br
CAS No. 541-22-0 SDF Download Decamethonium Bromide SDF
Smiles C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C.[Br-].[Br-]
Storage (From the date of receipt)

In vitro
Batch:

Water : 84 mg/mL

DMSO : 34 mg/mL ( (81.28 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 25 mg/mL


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In vivo
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Tech Support

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