Home Neuronal Signaling AChR agonist Choline Chloride For research use only.

Choline Chloride

Synonyms: Hepacholine

Choline chloride(Hepacholine) is a quaternary ammonium salt used as an additive for animal feed. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

Choline Chloride Chemical Structure

Choline Chloride Chemical Structure

CAS No. 67-48-1

Purity & Quality Control

Batch: S417101 DMSO]28 mg/mL]false]Water]28 mg/mL]false]Ethanol]28 mg/mL]false Purity: 100.0%
100.0

Choline Chloride Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description Choline chloride(Hepacholine) is a quaternary ammonium salt used as an additive for animal feed. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
In vitro
In vitro

Choline is a major part of the polar head group of phosphatidylcholine and a major part of another membrane phospholipid, sphingomyelin, which are very important for maintenance of cell structure and function. Choline deficiency in cell culture causes apoptosis or programmed cell death. Betaine or trimethylglycine is derived from choline via an oxidation reaction. Acetylcholine is one of the major neurotransmitters and requires choline for its synthesis. Adequate acetylcholine levels in the brain are believed to be protective against certain types of dementia, including Alzheimer's disease. Choline is also needed for gallbladder regulation, liver function and lecithin (a key lipid) formation. Choline also aids in fat and cholesterol metabolism and prevents excessive fat build up in the liver. Choline has been used to mitigate the effects of Parkinsonism and tardive dyskinesia. Choline deficiencies may result in excessive build-up of fat in the liver, high blood pressure, gastric ulcers, kidney and liver dysfunction and stunted growth.
In Vivo
In vivo

Choline chloride is of very low acute oral toxicity. The oral LD50 in rats is determined to be between 3150 and 5000 mg/kg bw. Clinical symptoms after application are restlessness, increased frequency of respiration, hypoactivity, convulsions, ruffled coat, staggered gait and dyspnoea. Some animals have diarrhoea and at necropsy in the high dose groups in one study 3 out of 10 rats have inflamed lungs.
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Chemical Information & Solubility

Molecular Weight 139.62 Formula

C5H14NO.Cl
CAS No. 67-48-1 SDF Download Choline Chloride SDF
Smiles C[N+](C)(C)CCO.[Cl-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 28 mg/mL ( (200.54 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 28 mg/mL

Ethanol : 28 mg/mL


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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