Home Neuronal Signaling AChR chemical Choline bitartrate For research use only.

Choline bitartrate

Synonyms: 2-hydroxyethyl(trimethyl)azanium;2,3,4-trihydroxy-4-oxobutanoate

Choline bitartrate (2-hydroxyethyl(trimethyl)azanium, 2,3,4-trihydroxy-4-oxobutanoate) is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcholine, a chemical that facilitates communication between the nerves and muscles.

Choline bitartrate Chemical Structure

Choline bitartrate Chemical Structure

CAS No. 87-67-2

Purity & Quality Control

Batch: S470301 Water]50 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 98.58%
98.58

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Signaling Pathway

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Biological Activity

Description Choline bitartrate (2-hydroxyethyl(trimethyl)azanium, 2,3,4-trihydroxy-4-oxobutanoate) is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcholine, a chemical that facilitates communication between the nerves and muscles.
In vitro
In vitro Choline is an essential nutrient needed for the structural integrity and signaling functions of cell membranes; for normal cholinergic neurotransmission; for normal muscle function; for lipid transport from liver; and it is the major source of methyl groups in the diet[3].
In Vivo
In vivo Choline is critical for normal brain development. Choline deficiency has other health consequences—it is associated with liver and muscle damage and with an exaggerated plasma homocysteine rise after a methionine load. Elevated plasma homocysteine is an independent risk factor for cardiovascular disease and stroke in humans[3]. But choline bitartrate does not improve remembrance of spatial locations, declarative items, and verbal words[1].
Animal Research Animal Models C57BL/6J mice
Dosages 5.0 g/kg
Administration oral administration

Chemical Information & Solubility

Molecular Weight 253.25 Formula

C5H14NO.C4H5O6
CAS No. 87-67-2 SDF Download Choline bitartrate SDF
Smiles C[N+](C)(C)CCO.C(C(C(=O)[O-])O)(C(=O)O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 50 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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