Home Metabolism AChR agonist Cevimeline HCl hemihydrate For research use only.

Cevimeline HCl hemihydrate

Synonyms: AF 102B, SNI 2011, SNK 508

Cevimeline HCl hemihydrate(AF 102B, SNI 2011, SNK 508) is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3.

Cevimeline HCl hemihydrate Chemical Structure

Cevimeline HCl hemihydrate Chemical Structure

CAS No. 153504-70-2

Purity & Quality Control

Batch: S643201 DMSO]40 mg/mL]false]Water]40 mg/mL]false]Ethanol]40 mg/mL]false Purity: 98.06%
98.06

Cevimeline HCl hemihydrate Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description Cevimeline HCl hemihydrate(AF 102B, SNI 2011, SNK 508) is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00466388 Completed
Xerostomia
American Academy of Otolaryngology-Head and Neck Surgery Foundation|Duke University
 May 2007 Phase 4

Chemical Information & Solubility

Molecular Weight 244.78 Formula

C10H18ClNOS.1/2H2O
CAS No. 153504-70-2 SDF --
Smiles CC1OC2(CN3CCC2CC3)CS1.CC1OC2(CN3CCC2CC3)CS1.O.Cl.Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 40 mg/mL ( (163.41 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 40 mg/mL

Ethanol : 40 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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