Home GPCR & G Protein CGRP Receptor antagonist Rimegepant (BMS-927711) For research use only.

Rimegepant (BMS-927711)

Synonyms: BHV-3000

Rimegepant (BMS-927711, BHV-3000) is a potent, selective, competitive human calcitonin gene-related peptide (CGRP) receptor antagonist with ki of 0.027 nM.

Rimegepant (BMS-927711) Chemical Structure

Rimegepant (BMS-927711) Chemical Structure

CAS No. 1289023-67-1

Purity & Quality Control

Rimegepant (BMS-927711) Related Products

Biological Activity

Description Rimegepant (BMS-927711, BHV-3000) is a potent, selective, competitive human calcitonin gene-related peptide (CGRP) receptor antagonist with ki of 0.027 nM.
Targets
CGRP receptor [1]
(Cell-free assay)
0.027 nM(Ki)
In vitro
In vitro

Rimegepant (BMS-927711, BHV-3000) is a potent, selective, competitive human calcitonin gene-related peptide (CGRP) receptor antagonist with ki of 0.027 nM.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06409832 Recruiting
Migraine|Migraine With Aura|Migraine Without Aura|Chronic Migraine
University of Florence|IRCCS National Neurological Institute C. Mondino Foundation|Società italiana per lo studio delle Cefalee (SISC)|Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari|Università degli Studi dell''Aquila|University of Roma La Sapienza|Azienda Ospedaliero Universitaria Policlinico Modena|Ospedale di Piove di Sacco|Azienda Ospedaliero-Universitaria di Parma|Azienda Ospedaliera S. Maria della Misericordia|Azienda Ospedaliera Città della Salute e della Scienza di Torino|Cliniche Humanitas Gavazzeni|University of Campania Luigi Vanvitelli|Ospedale di Prato|Azienda Policlinico Umberto I|Auxologico San Luca Milano|ASST Spedali Civili Brescia|Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
 March 26 2024 --
NCT05888766 Not yet recruiting
Migraine Disorders
University of Roma La Sapienza
 July 1 2023 --
NCT05518123 Recruiting
Migraine
Pfizer
 November 7 2022 Phase 4
NCT05509400 Recruiting
Migraine
Pfizer
 October 18 2022 Phase 4
NCT05399485 Active not recruiting
Migraine
Pfizer
 August 9 2022 Phase 3
NCT05262517 Terminated
Temporomandibular Disorders (TMD)
Pfizer
 May 5 2022 Phase 3

Chemical Information & Solubility

Molecular Weight 534.56 Formula

C28H28F2N6O3
CAS No. 1289023-67-1 SDF --
Smiles C1CC(C2=C(C=CC=N2)C(C1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (187.06 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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