Home Metabolism PDE inhibitor BI-409306 For research use only.

BI-409306

Synonyms: SUB 166499

BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM, respectively. Treatment with BI 409306 increases brain cGMP levels, promotes long-term potentiation, and improves episodic and working memory performance in rodents.

BI-409306 Chemical Structure

BI-409306 Chemical Structure

CAS No. 1189767-28-9

Purity & Quality Control

Batch: S003901 DMSO]62 mg/mL]false]Ethanol]4 mg/mL]false]Water]˂1 mg/mL]false Purity: 99.91%
99.91

BI-409306 Related Products

Signaling Pathway

PDE Signaling Pathways

PDE Signaling Pathway

Biological Activity

Description BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM, respectively. Treatment with BI 409306 increases brain cGMP levels, promotes long-term potentiation, and improves episodic and working memory performance in rodents.
Targets
human PDE9A [1]
(Cell-free assay)		 rat PDE9A [1]
(Cell-free assay)
65 nM 168 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03505151 Completed
Healthy
Boehringer Ingelheim
 April 27 2018 Phase 1
NCT03193307 Completed
Healthy
Boehringer Ingelheim
 June 29 2017 Phase 1
NCT03151499 Completed
Healthy
Boehringer Ingelheim
 May 30 2017 Phase 1
NCT02597998 Completed
Healthy
Boehringer Ingelheim
 September 15 2015 Phase 1

Chemical Information & Solubility

Molecular Weight 311.34 Formula

C16H17N5O2
CAS No. 1189767-28-9 SDF --
Smiles C1COCCC1N2C3=C(C=N2)C(=O)NC(=N3)CC4=CC=CC=N4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 62 mg/mL ( (199.13 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 4 mg/mL

Water : ˂1 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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