Home Metabolism PDE inhibitor BI 1015550 For research use only.

BI 1015550

BI 1015550 is an orally active inhibitor of PDE4B with IC50 of 7.2 nM. It has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD).

BI 1015550 Chemical Structure

BI 1015550 Chemical Structure

CAS No. 1423719-30-5

Purity & Quality Control

Batch: E138201 DMSO]11 mg/mL]false]Ethanol]5 mg/mL]false]Water]Insoluble]false Purity: 99.54%
99.54

BI 1015550 Related Products

Signaling Pathway

PDE Signaling Pathways

PDE Signaling Pathway

Biological Activity

Description BI 1015550 is an orally active inhibitor of PDE4B with IC50 of 7.2 nM. It has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD).
Targets
PDE4B [1]
7.2 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06241560 Not yet recruiting
Idiopathic Pulmonary Fibrosis
Boehringer Ingelheim
 August 6 2024 Phase 2
NCT06107036 Recruiting
Healthy
Boehringer Ingelheim
 March 4 2024 Phase 1
NCT05718648 Completed
Renal Insufficiency|Healthy
Boehringer Ingelheim
 February 9 2023 Phase 1
NCT04771286 Completed
Healthy
Boehringer Ingelheim
 March 25 2021 Phase 1
NCT03422068 Completed
Idiopathic Pulmonary Fibrosis
Boehringer Ingelheim
 March 16 2018 Phase 1

Chemical Information & Solubility

Molecular Weight 448.97 Formula

C20H25ClN6O2S
CAS No. 1423719-30-5 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 11 mg/mL ( (24.5 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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