Home Neuronal Signaling Histamine Receptor antagonist - COVID-19 inhibitor Bepotastine For research use only.

Bepotastine

Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor that is indicated in allergic rhinitis, urticaria, and pruritus associated with skin disease.

Bepotastine Chemical Structure

Bepotastine Chemical Structure

CAS No. 125602-71-3

Purity & Quality Control

Bepotastine Related Products

Signaling Pathway

Histamine Receptor Signaling Pathways

Histamine Receptor Signaling Pathway

Biological Activity

Description Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor that is indicated in allergic rhinitis, urticaria, and pruritus associated with skin disease.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01925313 Completed
Healthy
HK inno.N Corporation
 December 2012 Phase 1
NCT01425632 Completed
Perennial Allergic Rhinitis
Mitsubishi Tanabe Pharma Corporation
 August 2011 Phase 3

Chemical Information & Solubility

Molecular Weight 388.89 Formula

C21H25ClN2O3
CAS No. 125602-71-3 SDF --
Smiles C1CN(CCC1OC(C2=CC=C(C=C2)Cl)C3=CC=CC=N3)CCCC(=O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 78 mg/mL ( (200.57 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 78 mg/mL

Ethanol : 78 mg/mL


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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