Home Neuronal Signaling AChR antagonist - Adrenergic Receptor agonist Batefenterol  For research use only.

Batefenterol 

Synonyms: GSK961081, TD-5959

Batefenterol (GSK961081, TD-5959) is both a muscarinic receptor antagonist and a β2-adrenoceptor agonist with Ki of 1.4 nM, 1.3 nM and 3.7 nM for hM2, hM3 muscarinic receptors and hβ2-adrenoceptor, respectively.

Batefenterol  Chemical Structure

Batefenterol  Chemical Structure

CAS No. 743461-65-6

Purity & Quality Control

Batch: S003201 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.09%
99.09

Batefenterol  Related Products

Signaling Pathway

AChR Signaling Pathways

AChR Signaling Pathway

Biological Activity

Description Batefenterol (GSK961081, TD-5959) is both a muscarinic receptor antagonist and a β2-adrenoceptor agonist with Ki of 1.4 nM, 1.3 nM and 3.7 nM for hM2, hM3 muscarinic receptors and hβ2-adrenoceptor, respectively.
Targets
hM3 muscarinic receptor [1]
(Cell-free assay)		 hM2 muscarinic receptor [1]
(Cell-free assay)		 hβ2-adrenoceptor [1]
(Cell-free assay)
1.3 nM(Ki) 1.4 nM(Ki) 3.7 nM(Ki)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02064504 Completed
Pulmonary Disease Chronic Obstructive
GlaxoSmithKline
 February 19 2014 Phase 1
NCT00550225 Completed
Pulmonary Disease Chronic Obstructive
Theravance Biopharma|GlaxoSmithKline
 November 29 2007 Phase 1

Chemical Information & Solubility

Molecular Weight 740.24 Formula

C40H42ClN5O7
CAS No. 743461-65-6 SDF --
Smiles COC1=CC(=C(C=C1CNCC(C2=C3C=CC(=O)NC3=C(C=C2)O)O)Cl)NC(=O)CCN4CCC(CC4)OC(=O)NC5=CC=CC=C5C6=CC=CC=C6
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (135.09 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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