Home MAPK ERK inhibitor ASN007 For research use only.

ASN007

Synonyms: ERAS 007,ERK-IN-3

ASN007(ERAS 007, ERK-IN-3) is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with 2 nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations.

ASN007 Chemical Structure

ASN007 Chemical Structure

CAS No. 2055597-12-9

Purity & Quality Control

Batch: S997501 DMSO]95 mg/mL]false]Ethanol]95 mg/mL]false]Water]Insoluble]false Purity: 99.05%
99.05

ASN007 Related Products

Signaling Pathway

ERK Signaling Pathways

ERK Signaling Pathway

Biological Activity

Description ASN007(ERAS 007, ERK-IN-3) is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with 2 nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations.
Targets
ERK1/2 [1]
2 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04866134 Active not recruiting
Advanced or Metastatic Solid Tumors
Erasca Inc.
 May 7 2021 Phase 1|Phase 2
NCT03415126 Completed
Cancer|Malignancy|Neoplasia|Neoplasm|Neoplasm Metastasis|Colon Cancer|Colonic Neoplasms|Colon Cancer Liver Metastasis|Metastatic Cancer|Metastatic Melanoma|Metastatic Colon Cancer|Metastatic Lung Cancer|Non Small Cell Lung Cancer Metastatic|Pancreatic Cancer|Pancreas Cancer|Pancreas Adenocarcinoma|Pancreas Neoplasm|Metastatic Nonsmall Cell Lung Cancer|Metastatic Pancreatic Cancer
Asana BioSciences
 January 19 2018 Phase 1

Chemical Information & Solubility

Molecular Weight 473.93 Formula

C22H25ClFN7O2
CAS No. 2055597-12-9 SDF --
Smiles CC1=CN=C(NC2CCOCC2)N=C1[N]3C=NC(=C3)C(=O)NC(CN)C4=CC(=CC(=C4)F)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 95 mg/mL ( (200.45 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 95 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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