Home MAPK ERK activator - Nrf2 activator - Bcl-2 activator - Caspase inhibitor - Apoptosis related inhibitor Senkyunolide I For research use only.

Senkyunolide I

Synonyms: SEI, SENI

Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. Senkyunolide I (SEI, SENI) up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. Senkyunolide I (SEI, SENI) promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9.

Senkyunolide I Chemical Structure

Senkyunolide I Chemical Structure

CAS No. 94596-28-8

Purity & Quality Control

Senkyunolide I Related Products

Signaling Pathway

ERK Signaling Pathways

ERK Signaling Pathway

Biological Activity

Description Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. Senkyunolide I (SEI, SENI) up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. Senkyunolide I (SEI, SENI) promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9.
Targets
Erk1 [1] Erk2 [1] Nrf2 [1] Bcl-2/Bax [1] Caspase-3 [1] Click to View More Targets
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06210776 Recruiting
HER2-positive Breast Cancer|HER2-low Breast Cancer|Breast Cancer|Advanced Cancer
Daiichi Sankyo
 January 15 2024 --
NCT05592483 Recruiting
Breast Cancer
AstraZeneca
 July 7 2023 --
NCT06405399 Completed
Anaphylactic Reaction
Clinica Universidad de Navarra Universidad de Navarra
 May 10 2023 Not Applicable
NCT05013996 Recruiting
Offense Sex
University Hospital Tours
 January 20 2022 Not Applicable

Chemical Information & Solubility

Molecular Weight 224.25 Formula

C12H16O4
CAS No. 94596-28-8 SDF --
Smiles CCC\C=C1/OC(=O)C2=C1CCC(O)C2O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (445.93 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : 33 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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