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Technical Data
| Formula | C12H16O4 |
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| Molecular Weight | 224.25 | CAS No. | 94596-28-8 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (445.93 mM) | |
| Ethanol | 100 mg/mL (445.93 mM) | |||
| Water | 33 mg/mL (147.15 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. Senkyunolide I (SEI, SENI) up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. Senkyunolide I (SEI, SENI) promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9. | ||||||
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Protocol (from reference)
References
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Selleck's Senkyunolide I has been cited by 5 publications
| Melatonin alleviates high-fat-diet-induced dry eye by regulating macrophage polarization via IFT27 and lowering ERK/JNK phosphorylation [ iScience, 2024, 27(7):110367] | PubMed: 39100927 |
| Xuebijing improves intestinal microcirculation dysfunction in septic rats by regulating the VEGF-A/PI3K/Akt signaling pathway [ World J Emerg Med, 2024, 15(3):206-213] | PubMed: 38855370 |
| Ereg Silencing Inhibits Tumorigenesis Via Inactivating Erk/P38 Mapk Pathway in Pancreatic Ductal Adenocarcinoma [ SSRN , 2024, 10.2139/ssrn.4696834] | PubMed: none |
| ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment [ Cancer Biol Med, 2022, 19(11)j.issn.2095-3941.2022.0451] | PubMed: 36476328 |
| The protective effects of pericyte-derived microvesicles on vascular endothelial functions via CTGF delivery in sepsis [ Cell Commun Signal, 2021, 19(1):115] | PubMed: 34784912 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.