Home Endocrinology & Hormones GPR agonist AS1269574 For research use only.

AS1269574

AS 1269574, a small-molecule G protein-coupled receptor 119 (GPR119) agonist, has an EC50 of 2.5 μM in HEK293 cells transiently expressing human GPR119 and enhances insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8 mM) conditions.

AS1269574 Chemical Structure

AS1269574 Chemical Structure

CAS No. 330981-72-1

Purity & Quality Control

Batch: E034701 DMSO]62 mg/mL]false]Ethanol]62 mg/mL]false]Water]Insoluble]false Purity: 99.79%
99.79

AS1269574 Related Products

Biological Activity

Description AS 1269574, a small-molecule G protein-coupled receptor 119 (GPR119) agonist, has an EC50 of 2.5 μM in HEK293 cells transiently expressing human GPR119 and enhances insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8 mM) conditions.
Targets
IGF-1R [1] human GPR119 [1]
(in cAMP assay)
2.5 μM(EC50)

Chemical Information & Solubility

Molecular Weight 308.17 Formula

C13H14BrN3O
CAS No. 330981-72-1 SDF --
Smiles CC1=CC(=NC(=N1)C2=CC=C(Br)C=C2)NCCO
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 62 mg/mL ( (201.18 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 62 mg/mL

Water : Insoluble


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In vivo
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