Home Apoptosis Bcl-2 inhibitor APG-2575 (lisaftoclax) For research use only.

APG-2575 (lisaftoclax)

APG-2575 (lisaftoclax) is a dual Bcl-2 and Bcl-xl inhibitor with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively.

APG-2575 (lisaftoclax) Chemical Structure

APG-2575 (lisaftoclax) Chemical Structure

CAS No. 2180923-05-9

Purity & Quality Control

Batch: S997001 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.55%
99.55

APG-2575 (lisaftoclax) Related Products

Signaling Pathway

Bcl-2 Signaling Pathways

Bcl-2 Signaling Pathway

Biological Activity

Description APG-2575 (lisaftoclax) is a dual Bcl-2 and Bcl-xl inhibitor with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively.
Targets
Bcl-2 [1] Bcl-xl [1]
2 nM 5.9 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06182969 Not yet recruiting
SLE
Ascentage Pharma Group Inc.|Suzhou Yasheng Pharmaceutical Co. Ltd.
 December 2023 Phase 1|Phase 2
NCT05495035 Recruiting
Lymphoblastic Leukemia Acute Childhood|Leukemia Lymphoblastic Acute Philadelphia-Positive|Relapsed Leukemia|Refractory Leukemia
Institute of Hematology & Blood Diseases Hospital China
 September 1 2022 Phase 1
NCT04496349 Recruiting
T-Prolymphocytic Leukemia
Ascentage Pharma Group Inc.
 July 12 2021 Phase 2
NCT04494503 Recruiting
Chronic Lymphocytic Leukemia|Small Lymphocytic Lymphoma
Ascentage Pharma Group Inc.
 August 31 2020 Phase 1|Phase 2
NCT03913949 Active not recruiting
Chronic Lymphocytic Leukemia|Non Hodgkin Lymphoma
Ascentage Pharma Group Inc.|Suzhou Yasheng Pharmaceutical Co. Ltd.
 June 3 2019 Phase 1
NCT03537482 Recruiting
Hematologic Malignancies
Ascentage Pharma Group Inc.
 August 7 2018 Early Phase 1

Chemical Information & Solubility

Molecular Weight 882.43 Formula

C45H48ClN7O8S
CAS No. 2180923-05-9 SDF --
Smiles ClC1=CC=C(C=C1)C2=C(CCC3(CCC3)C2)CN4CCN(CC4)C5=CC(=C(C=C5)C(=O)N[S;v6](=O)(=O)C6=CC(=C(NCC7COCCO7)C=C6)[N;v5](=O)=O)OC8=CN=C9[NH]C=CC9=C8
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (113.32 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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