Home Apoptosis Bcl-2 modulator Ruxotemitide (LTX 315) For research use only.

Ruxotemitide (LTX 315)

Ruxotemitide (LTX 315) is the oncolytic peptide that kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.

Ruxotemitide (LTX 315) Chemical Structure

Ruxotemitide (LTX 315) Chemical Structure

CAS No. 1345407-05-7

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Ruxotemitide (LTX 315) Related Products

Signaling Pathway

Bcl-2 Signaling Pathways

Bcl-2 Signaling Pathway

Biological Activity

Description Ruxotemitide (LTX 315) is the oncolytic peptide that kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.
In vitro
In vitro LTX-315 is highly active against both murine and human melanoma cell lines in vitro. while displaying low EC50 cytotoxic activity against human red blood cells. LTX-315 has been shown to induce the release of ATP and HMGB1 in vitro, both being DAMPs involved in ICD[1].
Experimental Result Images Methods Biomarkers Images PMID
Immunofluorescence SMAC BAX 26378049
Growth inhibition assay Cell viability 21453492
In Vivo
In vivo when syngeneic B16 melanomas are treated intralesionally, a majority of the animals (~80%) treated with LTX-315 experience a complete and long-lasting tumor regression. LTX-315 injection induces an extensive hemorrhagic necrosis of the tumor parenchyma and a massive infiltration of CD3+ T cells, indicating that the peptide induces a type of cell death that leads to an increase in the number of tumor-infiltrating lymphocytes (TILs). treatment of a single tumor with LTX-315 generates a systemic anti-tumor immune response that eradicated distant lesions and prevented reoccurrence following tumor rechallenge[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03725605 Completed
Soft Tissue Sarcoma
Lytix Biopharma AS|Herlev Hospital
 December 28 2018 Phase 2
NCT01223209 Completed
Carcinoma
Lytix Biopharma AS|Kael-GemVax Co. Ltd.
 August 2010 Phase 1
NCT01058616 Completed
Cancer With Transdermal Accessible Tumour
Lytix Biopharma AS|Oslo University Hospital|Karolinska University Hospital
 January 2010 Phase 1

Chemical Information & Solubility

Molecular Weight 1439.79 Formula

C78H106N18O9
CAS No. 1345407-05-7 SDF Download Ruxotemitide (LTX 315) SDF
Smiles C1=CC=C(C=C1)C(C2=CC=CC=C2)C(C(=O)NC(CCCCN)C(=O)N)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CNC8=CC=CC=C87)NC(=O)C(CCCCN)NC(=O)C(CCCCN)N
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In vitro
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Water : 100 mg/mL


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In vivo
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