Home Endocrinology & Hormones RAAS inhibitor - ACE inhibitor Angiotensin (1-7) For research use only.

Angiotensin (1-7)

Synonyms: Ang-(1-7), Angiotensin fragment 1-7

Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.

Angiotensin (1-7) Chemical Structure

Angiotensin (1-7) Chemical Structure

CAS No. 51833-78-4

Purity & Quality Control

Batch: S982001 Water]50 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.30%
99.30

Angiotensin (1-7) Related Products

Signaling Pathway

RAAS Signaling Pathways

RAAS Signaling Pathway

Biological Activity

Description Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.
Targets
Mas receptor [1] ACE [1]
0.65 μM
In vitro
In vitro

Angiotensin (1-7) prevents the decrease of the myotube diameter and MHC Levels Induced by myostatin in C2C12 cells. Angiotensin (1-7) decreases the myostatin-dependent increment of E3 ubiquitin ligases and ROS, the NF-κB signaling induced by myostatin, the myostatin-dependent activity through the mas receptor and Akt/PKB activity in C2C12 myotubes.[1]
Cell Research Cell lines C2C12 cells
Concentrations 10 nM
Incubation Time 30 min, 60 min
Method

The C2C12 cells are differentiated until day 5 by changing DMEM–FSB to DMEM supplemented with horse serum. The myotubes are incubated with 1 µg/ml of human recombinant myostatin and/or 10 nM of Angiotensin (1-7). The myotubes are treated with 10 µM of MK2206 for Akt/PKB inhibition, or 10 µM of A779 antagonist for Mas receptor inhibition. In brief, the procedure is as follows: differentiated cells are pre-treated with Angiotensin (1-7) for 30 or 60 min, depending on the experiments, and then treated with myostatin.
In Vivo
In vivo

Daily Angiotensin (1-7) administration significantly reduces colitis severity observable at both gross and histological levels in DSS treated mice. The anti-inflammatory effects of Angiotensin (1-7) treatment are associated with a reduction in the phosphorylated forms of p38 MAPK, ERK1/2 and Akt post DSS induction, the anti-inflammatory properties of Angiotensin (1-7) are in part mediated through reduction of Ang II levels.[3]
Animal Research Animal Models DSS treated mice
Dosages 0.01 mg/kg, 0.06 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06282965 Not yet recruiting
Traumatic Brain Injury
University of Arizona|United States Department of Defense
 March 2024 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 899.00 Formula

C41H62N12O11
CAS No. 51833-78-4 SDF --
Smiles CCC(C)C(NC(=O)C(CC1=CC=C(O)C=C1)NC(=O)C(NC(=O)C(CCCN=C(N)N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(CC2=CN=C[NH]2)C(=O)N3CCCC3C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 50 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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