Home Metabolism PDE inhibitor Anagrelide HCl For research use only.

Anagrelide HCl

Synonyms: BL-4162A,BMY 26538-01

Anagrelide (BL-4162A,BMY 26538-01) is a drug used for the treatment of essential thrombocytosis.

Anagrelide HCl Chemical Structure

Anagrelide HCl Chemical Structure

CAS No. 58579-51-4

Purity & Quality Control

Anagrelide HCl Related Products

Signaling Pathway

PDE Signaling Pathways

PDE Signaling Pathway

Biological Activity

Description Anagrelide (BL-4162A,BMY 26538-01) is a drug used for the treatment of essential thrombocytosis.
Targets
PDE [1]
In vitro
In vitro

Anagrelide is an oral imidazoquinazoline agent with an anti-cyclic AMP phosphodiesterase activity and inhibits platelet aggregation in both humans and animals. Anagrelide works by inhibiting the maturation of platelets from megakaryocytes.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03866434 Completed
Healthy Volunteers
Shire|Takeda
 February 26 2019 Phase 1
NCT02125318 Completed
Thrombocytosis|Myeloproliferative Neoplasms
Galena Biopharma Inc.
 May 2014 Phase 2
NCT01192347 Completed
Essential Thrombocythemia
Shire|Takeda
 September 13 2010 --

Chemical Information & Solubility

Molecular Weight 292.55 Formula

C10H7Cl2N3O.HCl
CAS No. 58579-51-4 SDF Download Anagrelide HCl SDF
Smiles C1C2=C(C=CC(=C2Cl)Cl)N=C3N1CC(=O)N3.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 14 mg/mL ( (47.85 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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