Home Transmembrane Transporters Sodium Channel inhibitor Ambroxol HCl For research use only.

Ambroxol HCl

AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.

Ambroxol HCl Chemical Structure

Ambroxol HCl Chemical Structure

CAS No. 23828-92-4

Purity & Quality Control

Ambroxol HCl Related Products

Signaling Pathway

Sodium Channel Signaling Pathways

Sodium Channel Signaling Pathway

Biological Activity

Description AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
Targets
Sodium channel [1]
35.2 μM-22.5 μM
In vitro
In vitro Ambroxol inhibits Na+ channels in sensory neurons. The potency for tonic block of TTX-r channels is relatively high. Ambroxol affects the Na+ current kinetics of TTX-r and TTX-s channels differently. In CNaIIA cells, the compound behaves like a charged local anesthetic: the block is dependent on stimulus number and increases with higher frequencies in a train of depolarizing stimuli. In CNaIIA cells, ambroxol inhibits inactivated channels 5.5-fold more potently than resting channels. The corresponding factor for TTX-r channels is only 3.3.[1] Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. [2]
In Vivo
In vivo Ambroxol inhibited histamine release by more than 50% from human adenoidal mast cells (1000 microM ambroxol) and skin mast cells (100 microM ambroxol) stimulated by Con A and compound 48/80, respectively. Ambroxol (100 microM) strikingly inhibited anti-IgE induced release of both histamine, LTC4, IL-4 and IL-13 from basophils and reduced both histamine and LTB4 release induced by C5a or Zymosan in monocytes. The drug also reduced LTB4 and superoxide anion production in granulocytes stimulated by zymosan or fMLP.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04405596 Not yet recruiting
Lewy Body Disease
Lawson Health Research Institute
 January 2025 Phase 1|Phase 2
NCT05778617 Not yet recruiting
Parkinson Disease
University College London
 September 2023 Phase 3
NCT05558878 Not yet recruiting
Diabetic Neuropathy Peripheral
Ain Shams University
 October 1 2022 Not Applicable
NCT05287503 Active not recruiting
Parkinson Disease|GBA Gene Mutation
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta|IRCCS National Neurological Institute C. Mondino Foundation|University of Campania Luigi Vanvitelli
 February 15 2022 Phase 2
NCT04388969 Recruiting
Gaucher Disease|Parkinson Disease|GBA Gene Mutation
Shaare Zedek Medical Center
 May 6 2020 --

Chemical Information & Solubility

Molecular Weight 414.56 Formula

C13H18Br2N2O.HCl
CAS No. 23828-92-4 SDF Download Ambroxol HCl SDF
Smiles C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 6 mg/mL ( (14.47 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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