Home Protein Tyrosine Kinase Ephrin receptor inhibitor ALW II-41-27 For research use only.

ALW II-41-27

ALW II-41-27 (compound 7) is a potent inhibitor of Eph receptor tyrosine kinase with Kd of 12 nM for EphA2.

ALW II-41-27 Chemical Structure

ALW II-41-27 Chemical Structure

CAS No. 1186206-79-0

Purity & Quality Control

ALW II-41-27 Related Products

Signaling Pathway

Ephrin receptor Signaling Pathways

Ephrin receptor Signaling Pathway

Biological Activity

Description ALW II-41-27 (compound 7) is a potent inhibitor of Eph receptor tyrosine kinase with Kd of 12 nM for EphA2.
Targets
EphA2 [1]
(Cell-free assay)
12 nM(Kd)
In vitro
In vitro

After ALW-II-41-27 (EPHA2 inhibitor) treatment (0.5 μM) in GM for 12 h, the phosphorylation of EPHA2 is decreased (P < 0.05).[2]
Cell Research Cell lines adipogenic and myogenic precursors cells
Concentrations 0.5 μM
Incubation Time 12 h
Method

To determine the role of EPHA2 in myogenic differentiation, myogenic precursors were treated with ALW-II-41-27 (0.5 μM) for 12 h in GM followed by myogenic differentiation.

Chemical Information & Solubility

Molecular Weight 607.69 Formula

C32H32F3N5O2S
CAS No. 1186206-79-0 SDF --
Smiles CCN1CCN(CC1)CC2=CC=C(NC(=O)C3=CC=C(C)C(=C3)NC(=O)C4=CC(=CN=C4)C5=CC=CS5)C=C2C(F)(F)F
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (164.55 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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