ALW II-41-27

Catalog No.S6515 Batch:S651501

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Technical Data

Formula

C32H32F3N5O2S
Molecular Weight 607.69 CAS No. 1186206-79-0
Solubility (25°C)* In vitro DMSO 100 mg/mL (164.55 mM)
Ethanol 100 mg/mL (164.55 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description ALW II-41-27 (compound 7) is a potent inhibitor of Eph receptor tyrosine kinase with Kd of 12 nM for EphA2.
Targets
EphA2 [1]
(Cell-free assay)
12 nM(Kd)
In vitro

After ALW-II-41-27 (EPHA2 inhibitor) treatment (0.5 μM) in GM for 12 h, the phosphorylation of EPHA2 is decreased (P < 0.05).[2]

Protocol (from reference)

Cell Assay:[2]
  • Cell lines

    adipogenic and myogenic precursors cells

  • Concentrations

    0.5 μM

  • Incubation Time

    12 h

  • Method

    To determine the role of EPHA2 in myogenic differentiation, myogenic precursors were treated with ALW-II-41-27 (0.5 μM) for 12 h in GM followed by myogenic differentiation.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.