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Triamcinolone Acetonide

Name: Triamcinolone Acetonide
Brand: Selleck Chemicals
SKU: S1628
Rating: 5 (4 reviews)

Catalog No.S1628 Purity:100%

Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.

Triamcinolone Acetonide Chemical Structure

CAS No. 76-25-5

Purity & Quality Control

Batch: Purity: 100%

100

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Biological Activity

Description

Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.

Targets

Glucocorticoid receptor ^[1]

In vitro
In vitro	Triamcinolone Acetonide significantly decreases the paracellular permeability of ECV304 cells and down-regulated ICAM-1 expression, consistent with immunocytochemical observations. ^[1] Triamcinolone reverses the osmotic swelling of glial cells in retinas of the rat that is observed under various experimental conditions: in retinas isolated at 3 days after transient retinal ischemia, in retinas of eyes with lipopolysaccharide-induced ocular inflammation, and in control retinas in the presence of Ba^{2+^{(1 mM), H₂O₂ (200 mM), arachidonic acid (10 mM), or prostaglandin E2 (30 nM). ^[2] Triamcinolone Acetonide reduces GAG synthesis compared to control and IL-1 alone. Triamcinolone Acetonide increases GAG degradation. Triamcinolone Acetonide increases media GAG content compared to control and IL-1 explants. ^[3]}}

In Vivo
In vivo	Triamcinolone Acetonide (TAC), a synthetic glucocorticoid, induces cleft palate resulting from poor development of palatal shelves in mice. Triamcinolone Acetonide inhibits the proliferation of mesenchymal cells and affects the differentiation of MEE cells into stratified squamous epithelia in the palatal shelves of rat embryos. ^[4] Triamcinolone Acetonide reduces lameness, edema, and concentration of synovial fluid protein after the second LPS injection in horse. Triamcinolone Acetonide also induces higher WBC counts and mepivacaine concentrations in synovial fluid, compared with results for Mepivacaine alone. ^[5]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT04658836	Completed	Vestibular Schwannoma	Medical University of Vienna	February 1 2020	Phase 1
NCT03378076	Completed	Bilateral Knee Osteoarthritis	Pacira Pharmaceuticals Inc	December 6 2017	Phase 2
NCT03382262	Completed	Osteoarthritis of the Shoulder\|Osteoarthritis of the Hip	Pacira Pharmaceuticals Inc	December 18 2017	Phase 2

References

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Chemical Information & Solubility

Molecular Weight	434.5	Formula	C₂₄H₃₁FO₆
CAS No.	76-25-5	SDF	Download Triamcinolone Acetonide SDF
Smiles	CC1(OC2CC3C4CCC5=CC(=O)C=CC5(C4(C(CC3(C2(O1)C(=O)CO)C)O)F)C)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 87 mg/mL ( (200.23 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 13 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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