Triamcinolone Acetonide

Catalog No.S1628 Batch:S162803

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Technical Data

Formula

C24H31FO6
Molecular Weight 434.5 CAS No. 76-25-5
Solubility (25°C)* In vitro DMSO 86 mg/mL (197.92 mM)
Ethanol 20 mg/mL (46.02 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Triamcinolone acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.
Targets
Glucocorticoid receptor [1]
In vitro Triamcinolone Acetonide significantly decreases the paracellular permeability of ECV304 cells and down-regulated ICAM-1 expression, consistent with immunocytochemical observations. [1] Triamcinolone reverses the osmotic swelling of glial cells in retinas of the rat that is observed under various experimental conditions: in retinas isolated at 3 days after transient retinal ischemia, in retinas of eyes with lipopolysaccharide-induced ocular inflammation, and in control retinas in the presence of Ba2+ (1 mM), H2O2 (200 mM), arachidonic acid (10 mM), or prostaglandin E2 (30 nM). [2] Triamcinolone Acetonide reduces GAG synthesis compared to control and IL-1 alone. Triamcinolone Acetonide increases GAG degradation. Triamcinolone Acetonide increases media GAG content compared to control and IL-1 explants. [3]
In vivo Triamcinolone Acetonide (TAC), a synthetic glucocorticoid, induces cleft palate resulting from poor development of palatal shelves in mice. Triamcinolone Acetonide inhibits the proliferation of mesenchymal cells and affects the differentiation of MEE cells into stratified squamous epithelia in the palatal shelves of rat embryos. [4] Triamcinolone Acetonide reduces lameness, edema, and concentration of synovial fluid protein after the second LPS injection in horse. Triamcinolone Acetonide also induces higher WBC counts and mepivacaine concentrations in synovial fluid, compared with results for Mepivacaine alone. [5]

Protocol (from reference)

Selleck's Triamcinolone Acetonide has been cited by 4 publications

Estrogen antagonizes ASIC1a-induced chondrocyte mitochondrial stress in rheumatoid arthritis [ J Transl Med, 2022, 20(1):561] PubMed: 36463203
Estrogen Protects Articular Cartilage by Downregulating ASIC1a in Rheumatoid Arthritis [ J Inflamm Res, 2021, 14:843-858] PubMed: 33737825
ASIC1a induces synovial inflammation via the Ca2+/NFATc3/ RANTES pathway. [ Theranostics, 2020, 10(1):247-264] PubMed: 31903118
High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction [ Drug Test Anal, 2020, 10.1002/dta.2917] PubMed: 32852861

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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