Home Metabolism Lipase inhibitor Tanshinone IIA For research use only.

Tanshinone IIA

Synonyms: Tanshinone B

Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.

Tanshinone IIA Chemical Structure

Tanshinone IIA Chemical Structure

CAS No. 568-72-9

Purity & Quality Control

Tanshinone IIA Related Products

Biological Activity

Description Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor.
Targets
monoacylglycerol lipase [4]
In vitro
In vitro Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases. Tanshinone IIA protects cardiac myocytes against oxidative stress-induced apoptosis. The in vivo protection is mediated by increased scavenging of oxygen free radicals, prevention of lipid peroxidation and upregulation of the Bcl-2/Bax ratio. [1] Recently, tanshinone IIA was demonstrated to induce cell death and apoptosis in a variety of tumors. [2]
In Vivo
In vivo LD50: Rats 25g/kg (i.g.) [3]

Chemical Information & Solubility

Molecular Weight 294.34 Formula

C19H18O3
CAS No. 568-72-9 SDF Download Tanshinone IIA SDF
Smiles CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 1 mg/mL ( (3.39 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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