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Formula | C19H18O3 |
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Molecular Weight | 294.34 | CAS No. | 568-72-9 | |
Solubility (25°C)* | In vitro | DMSO | 5 mg/mL (16.98 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases; A natural monoacylglycerol lipase inhibitor. | |
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In vitro | Tanshinone IIA (Tanshinone B) is the most abundant diterpene quinone in Danshen, Salviae miltiorrhizae Radix, a widely prescribed traditional herbal medicine that is used to treat cardiovascular and inflammatory diseases. Tanshinone IIA protects cardiac myocytes against oxidative stress-induced apoptosis. The in vivo protection is mediated by increased scavenging of oxygen free radicals, prevention of lipid peroxidation and upregulation of the Bcl-2/Bax ratio. [1] Recently, tanshinone IIA was demonstrated to induce cell death and apoptosis in a variety of tumors. [2] | |
In vivo | LD50: Rats 25g/kg (i.g.) [3] |
Data from [Data independently produced by , , Cancer Lett, 2017, 403:86-97]
Data from [Data independently produced by , , Biomed Pharmacother, 2018, 105:758-765]
Tanshinone IIA induces ER stress and JNK activation to inhibit tumor growth and enhance anti-PD-1 immunotherapy in non-small cell lung cancer [ Phytomedicine, 2024, 128:155431] | PubMed: 38537440 |
Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma [ J Cancer, 2023, 14(13):2481-2490] | PubMed: 37670974 |
Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma [ J Cancer, 2023, 14(13):2481-2490] | PubMed: 37670974 |
Tan IIA mitigates vascular smooth muscle cell proliferation and migration induced by ox-LDL through the miR-137/TRPC3 axis [ Kaohsiung J Med Sci, 2023, 10.1002/kjm2.12663] | PubMed: 36912285 |
Tanshinone IIA regulates expression of glucose transporter 1 via activation of the HIF‑1α signaling pathway [ Mol Med Rep, 2022, 26(5)328] | PubMed: 36069225 |
Tanshinone IIA enhances the ovarian reserve and attenuates ovarian oxidative stress in aged mice [ Vet Med Sci, 2022, 10.1002/vms3.811] | PubMed: 35451235 |
Tanshinone IIA regulates microRNA‑125b/foxp3/caspase‑1 signaling and inhibits cell viability of nasopharyngeal carcinoma [ Mol Med Rep, 2021, 23(5)371] | PubMed: 33760137 |
Tanshinone IIA protects human coronary artery endothelial cells from ferroptosis by activating the NRF2 pathway [ Biochem Biophys Res Commun, 2021, 575:1-7] | PubMed: 34454174 |
Tanshinone IIA Inhibits Epithelial-to-Mesenchymal Transition Through Hindering β-Arrestin1 Mediated β-Catenin Signaling Pathway in Colorectal Cancer [ Front Pharmacol, 2020, 11:586616] | PubMed: 33192529 |
Tanshinone IIA Suppresses Proliferation and Inflammatory Cytokine Production of Synovial Fibroblasts From Rheumatoid Arthritis Patients Induced by TNF-α and Attenuates the Inflammatory Response in AIA Mice [ Front Pharmacol, 2020, 15;11:568] | PubMed: 32499694 |
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