Home Transmembrane Transporters Sodium Channel inhibitor Propafenone HCl For research use only.

Propafenone HCl

Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.

Propafenone HCl Chemical Structure

Propafenone HCl Chemical Structure

CAS No. 34183-22-7

Purity & Quality Control

Batch: S250001 DMSO]3.125 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.78%
99.78

Propafenone HCl Related Products

Signaling Pathway

Sodium Channel Signaling Pathways

Sodium Channel Signaling Pathway

Biological Activity

Description Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
Targets
Sodium channel [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03915340 Completed
Bioequivalence
Pharmtechnology LLC|Altasciences Company Inc.
 March 23 2019 Phase 1
NCT03029169 Completed
Supraventricular Arrhythmia|Septic Shock
Charles University Czech Republic
 October 23 2017 Phase 4

Chemical Information & Solubility

Molecular Weight 377.9 Formula

C21H27NO3.HCl
CAS No. 34183-22-7 SDF Download Propafenone HCl SDF
Smiles CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 3.125 mg/mL ( (8.26 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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