Home Endocrinology & Hormones Glucocorticoid Receptor agonist - Immunology & Inflammation related inhibitor Prednisone For research use only.

Prednisone

Synonyms: Adasone,NSC-10023

Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.

Prednisone Chemical Structure

Prednisone Chemical Structure

CAS No. 53-03-2

Purity & Quality Control

Prednisone Related Products

Biological Activity

Description Prednisone is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
Targets
Glucocorticoid receptor [1]
In vitro
In vitro Prednisone blocks Peripheral blood lymphocytes (PBL) growth in the G1 phase of cell cycle and inhibits both IL-2 receptor (IL-2R) expression and IL-2 secretion in activated human peripheral blood T lymphocytes. Prednisone increases apoptosis in PHA-activated human PBL, and the apoptotic effect of Prednisone is stronger on CD8(+) than on CD4(+) T lymphocytes. [1]
In Vivo
In vivo Prednisone-treated rats show a significant delay of 20% in learning and memory retention in rats as compared with controls. [2] Prednisone results in reduced weight gain, unchanged alter uterine weight, lowered serum magnesium (Mg), unchange serum calcium (Ca), phosphate (P), 25-hydroxyvitamin D (25OHD), or 1,25-dihydroxyvitamin D [1,25(OH)2D], striking increased in calcified cartilage, reduced cross-sectional area and cortical area, unchange medullary area of the tibial diaphysis, lowered periosteal and endocortical bone formation and apposition rates, increased mean cancellous bone area and cancellous bone perimeter of the tibial metaphysis in both sham-operated and ovariectomized rats. [3] Prednisone-treated rabbit shows a 30% reduction in percent stenosis, a 35% decrease in neointimal area, and a 66% decrement in neointimal thickness. [4] Prednisone treatment significantly reduces the level of TGF-beta1 and HYP in diaphragm from mdx mice to values similar to control mice, but results in a higher level of the HP cross-link compared with untreated mdx mice. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06337695 Not yet recruiting
Cancer|Cancer Metastatic
University of Calgary
 July 1 2024 Phase 2|Phase 3
NCT06394063 Not yet recruiting
Systemic Lupus Erythematosus
RenJi Hospital
 June 30 2024 Not Applicable
NCT06360068 Not yet recruiting
Systemic Lupus Erythematosus
Qiong Fu|RenJi Hospital
 May 6 2024 Phase 2
NCT06037811 Not yet recruiting
Inflammatory Arthritis|Immune-related Adverse Event
Tom Appleton|Canadian Research Group in Immuno-Oncology|Western University|Lawson Health Research Institute
 April 2024 Phase 2

Chemical Information & Solubility

Molecular Weight 358.43 Formula

C21H26O5
CAS No. 53-03-2 SDF Download Prednisone SDF
Smiles CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 71 mg/mL ( (198.08 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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