Home Transmembrane Transporters Sodium Channel inhibitor Phenytoin For research use only.

Phenytoin

Synonyms: Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722

Phenytoin (Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722) is an inactive voltage-gated sodium channel stabilizer.

Phenytoin Chemical Structure

Phenytoin Chemical Structure

CAS No. 57-41-0

Purity & Quality Control

Phenytoin Related Products

Signaling Pathway

Sodium Channel Signaling Pathways

Sodium Channel Signaling Pathway

Biological Activity

Description Phenytoin (Di-Hydan, Dihycon, Dilabid, Diphedan, Diphenat, Diphenylan, Diphenylhydantoin, Hydantol, Lehydan, NSC 8722) is an inactive voltage-gated sodium channel stabilizer.
Targets
Sodium channel [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06403150 Enrolling by invitation
Status Epilepticus
Dhaka Medical College
 May 15 2023 Phase 4
NCT06067412 Completed
Status Epilepticus
Shaheed Zulfiqar Ali Bhutto Medical University
 August 1 2022 Not Applicable
NCT04647877 Completed
Chronic Idiopathic Axonal Polyneuropathy
David J. Kopsky|Princess Beatrix Muscle Foundation|Dr. C.J. Vaillant Fonds|UMC Utrecht
 September 17 2020 Phase 2|Phase 3
NCT04829838 Unknown status
Status Epilepticus
ayesha tariq|King Edward Medical University
 July 25 2019 Phase 4
NCT01635829 Completed
Healthy Participants
Janssen Infectious Diseases BVBA
 May 2012 Phase 1

Chemical Information & Solubility

Molecular Weight 252.27 Formula

C15H12N2O2
CAS No. 57-41-0 SDF Download Phenytoin SDF
Smiles C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 50 mg/mL ( (198.2 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 13 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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