Home Transmembrane Transporters Sodium Channel inhibitor Oxcarbazepine For research use only.

Oxcarbazepine

Synonyms: GP47680

Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.

Oxcarbazepine Chemical Structure

Oxcarbazepine Chemical Structure

CAS No. 28721-07-5

Purity & Quality Control

Batch: S139101 DMSO]7 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.95%
99.95

Oxcarbazepine Related Products

Signaling Pathway

Sodium Channel Signaling Pathways

Sodium Channel Signaling Pathway

Biological Activity

Description Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.
Targets
sodium channel [1]
160 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02104661 Completed
Multiple Sclerosis
Queen Mary University of London|National Multiple Sclerosis Society|Novartis Pharmaceuticals|Barts & The London NHS Trust|University College London|Royal Free Hospital NHS Foundation Trust|Mid and South Essex NHS Foundation Trust|St George''s Healthcare NHS Trust|Barnet and Chase Farm Hospitals NHS Trust
 October 2014 Phase 2
NCT02098941 Unknown status
Epilepsy
Seoul National University Hospital|Janssen Korea Ltd. Korea
 March 2014 --
NCT02362373 Completed
Epilepsy|Contraception
Columbia University|Bayer
 August 2011 Phase 4
NCT00951847 Completed
Healthy
Ranbaxy Laboratories Limited|Ranbaxy Inc.
 October 2006 Not Applicable
NCT00951600 Completed
Healthy
Ranbaxy Laboratories Limited|Ranbaxy Inc.
 September 2006 Not Applicable

Chemical Information & Solubility

Molecular Weight 252.27 Formula

C15H12N2O2
CAS No. 28721-07-5 SDF Download Oxcarbazepine SDF
Smiles C1C2=CC=CC=C2N(C3=CC=CC=C3C1=O)C(=O)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 7 mg/mL ( (27.74 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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