Home Metabolism FXR agonist Chenodeoxycholic Acid For research use only.

Chenodeoxycholic Acid

Synonyms: Chenodiol, Chenodesoxycholic acid, Chenocholic acid,CDCA

Chenodeoxycholic Acid (Chenodiol, Chenodesoxycholic acid, Chenocholic acid,CDCA) is a naturally occurring human bile acid, and inhibits production of cholesterol in the liver and absorption in the intestines. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

Chenodeoxycholic Acid Chemical Structure

Chenodeoxycholic Acid Chemical Structure

CAS No. 474-25-9

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Chenodeoxycholic Acid Related Products

Biological Activity

Description Chenodeoxycholic Acid (Chenodiol, Chenodesoxycholic acid, Chenocholic acid,CDCA) is a naturally occurring human bile acid, and inhibits production of cholesterol in the liver and absorption in the intestines. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
In vitro
In vitro

Chenodeoxycholic acid (CDCA) and Deoxycholic acid (DCA) both inhibits 11 beta HSD2 with IC(50) values of 22 mM and 38 mM, respectively and causes cortisol-dependent nuclear translocation and increases transcriptionalactivity of mineralocorticoid receptor (MR). [1] Chenodeoxycholic acid is able to stimulate Ishikawa cell growth by inducing a significant increase in Cyclin D1 protein and mRNA expression through the activation of the membrane G protein-coupled receptor (TGR5)-dependent pathway. [2] Chenodeoxycholic acid (CDCA) induces LDL receptor mRNA levels approximately 4 fold and mRNA levels for HMG-CoA reductase and HMG-CoA synthase two fold in a cultured human hepatoblastoma cell line, Hep G2. [3] Chenodeoxycholic acid-induced Isc is inhibited (≥67%) by Bumetanide, BaCl2, and the cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor CFTRinh-172. Chenodeoxycholic acid-stimulated Isc is decreased 43% by the adenylate cyclase inhibitor MDL12330A and Chenodeoxycholic acid increases intracellular cAMP concentration. [4] Chenodeoxycholic acid treatment activates C/EBPβ, as shown by increases in its phosphorylation, nuclear accumulation, and expression in HepG2 cells. Chenodeoxycholic acid enhances luciferase gene transcription from the construct containing -1.65-kb GSTA2 promoter, which contains C/EBP response element (pGL-1651). Chenodeoxycholic acid treatment activates AMP-activated protein kinase (AMPK), which leads to extracellular signal-regulated kinase 1/2 (ERK1/2) activation, as evidenced by the results of experiments using a dominant-negative mutant of AMPKα and chemical inhibitor. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05130047 Completed
Chronic Diarrhea|Irritable Bowel Syndrome With Diarrhea|Bile Acid Malabsorption|Bile Acid Diarrhea|Bile Acid Malabsorption Syndrome Type II|Functional Diarrhea
Michael Camilleri MD|NGM Biopharmaceuticals Inc|Mayo Clinic
 December 1 2021 Phase 2
NCT03168555 Completed
Bile Acid Malabsorption|Cholelithiasis
Zealand University Hospital
 June 22 2017 Phase 4
NCT01865812 Completed
Primary Biliary Cirrhosis
Intercept Pharmaceuticals
 December 3 2013 Phase 2
NCT01570439 Unknown status
Anonymous Donors at Blood Donation Center (NUH)
National University Hospital Singapore
 January 2012 --

Chemical Information & Solubility

Molecular Weight 392.57 Formula

C24H40O4
CAS No. 474-25-9 SDF Download Chenodeoxycholic Acid SDF
Smiles CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 79 mg/mL ( (201.23 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 79 mg/mL

Water : Insoluble


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