Home Immunology & Inflammation IFN activator Aloe-emodin For research use only.

Aloe-emodin

Synonyms: NSC 38628, Rhabarberone

Aloe-emodin (NSC 38628, Rhabarberone) is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.

Aloe-emodin Chemical Structure

Aloe-emodin Chemical Structure

CAS No. 481-72-1

Purity & Quality Control

Aloe-emodin Related Products

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HCT116 cells Cytotoxicity assay 24 h Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay, IC50=8.7 μM 17949858
HepG2 cells Cytotoxicity assay 24 h Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay, IC50=10 μM 17949858
A2780 cells Cytotoxicity assay Cytotoxicity against human A2780 cells, IC50=26 μM 24326280
Click to View More Cell Line Experimental Data

Biological Activity

Description Aloe-emodin (NSC 38628, Rhabarberone) is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.

Chemical Information & Solubility

Molecular Weight 270.24 Formula

C15H10O5

CAS No. 481-72-1 SDF --
Smiles C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 8 mg/mL ( (29.6 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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